Brain structural changes associated with the onset of schizophrenia in individuals at risk for psychosis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461738
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Toyama
• Principal Investigator: Takayanagi Yoichiro 富山大学, 附属病院, 講師 (40574942)
• Co-Investigator(Kenkyū-buntansha): 鈴木 道雄 富山大学, 大学院医学薬学研究部(医学), 教授 (40236013) ; 高橋 努 富山大学, 大学院医学薬学研究部(医学), 准教授 (60345577)
• Co-Investigator(Renkei-kenkyūsha): MIZUNO Masafumi 東邦大学, 医学部, 教授 (80245589) ; MATSUMOTO Kazunori 東北大学, 医学(系)研究科(研究院), 准教授 (40301056) ; KASAI Kiyoto 東京大学, 医学部附属病院, 教授 (80322056)
• Research Collaborator: Ratnanather Tilak Johns Hopkins University, Center for Imaging Sciences, Associate Professor
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 統合失調症 / at-risk mental state / 磁気共鳴画像（MRI) / ハイリスク / 発症予測 / バイオマーカー / 多施設研究

Outline of Final Research Achievements

We conducted a multi-site structural neuroimaging study of individuals at risk for developing psychosis to obtain a large sample size. Using labeled cortical distance mapping and local gyrification index, we found brain structural changes which predate the onset of frank psychosis such as cortical thinning of the anterior cingulate gyrus, gray matter reduction of the dorsolateral prefrontal cortex, and hypergyrification of the occipital cortex. These structural changes may be useful for predicting the future transition to psychosis such as schizophrenia.

Free Research Field

精神医学