Assessment of neurophysiological changes with electroconvulsive therapy in mental disorders using nonlinear EEG approach

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461740
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Fukui
• Principal Investigator: Okazaki Ryoko 福井大学, 学術研究院医学系部門(附属病院部), 助教 (90647778)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 電気けいれん療法 / 神経ネットワーク / 脳波 / 非線形解析 / マルチスケールエントロピー解析 / うつ病 / 自閉スペクトラム症 / 強迫性障害

Outline of Final Research Achievements

Recently developed multiscale entropy analysis, which has underpinned aberrant functional connectivity in mental disorders, was introduced to explore changes in EEG complexity occurring with ECT in mental disorders.Depression patients demonstrated a decrease in EEG complexity, especially at higher frequencies. This decrease was associated with improvement of depressive symptoms. In ASD patient, along with ECT, the frontocentral region showed decreased EEG complexity, whereas the occipital region expressed an increase. Furthermore, these changes were associated with clinical improvement associated with the elevation of BDNF.
Multiscale entropy analysis might be a useful analytical method to elucidate neurophysiological mechanisms and evaluate the therapeutic efficacy of ECT in mental disorders.

Free Research Field

臨床精神医学