Investigation for the neural basis of apathy in dementia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461750
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University (2016); Kumamoto University (2014-2015)
• Principal Investigator: Ikeda Manabu 大阪大学, 医学系研究科, 教授 (60284395)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アパシー / 神経基盤 / 前頭側頭型認知症 / 意味性認知症 / アルツハイマー病 / MRI / SPECT

Outline of Final Research Achievements

We gathered Neuropsychiatric Inventory (NPI) data of patients with Alzheimer’s disease (AD; n = 1091), dementia with Lewy bodies (DLB; n = 249), vascular dementia (VaD; n = 156), and frontotemporal lobar degeneration (FTLD; n = 102). The progression of dementia was significantly associated with the severity of apathy in AD, DLB and VaD patients. However, trajectories of apathy in FTLD were unclear. Apathy was the most prevalent BPSD in AD, DLB, VaD, FTLD patients with almost all CDR stages.

Free Research Field

老年精神医学