Study of the default mode network by simultaneous measurement of functional MRI and EEG.

2018 Fiscal Year Final Research Report

• Project/Area Number: 26461757
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Juntendo University
• Principal Investigator: Eiji Kirino 順天堂大学, 医学部, 教授 (90276460)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Keywords: rs-fMRI / LORETA / schizophrenia / EEG / functional connectivity / ｄｅｆDefauｌｔ ｍｏｄｅ ｎｅｔｗｏｒｋ / 皮質線条体ネットワーク

Outline of Final Research Achievements

This study focused on the functional connectivity (FC) of the cortico-striatal network, which is thought to be disrupted in schizophrenia and to contribute to its clinical manifestations. We used simultaneous resting-state functional MRI (rsfMRI) and electroencephalography (EEG) recordings to investigate FC in patients with schizophrenia.
Compared to HCs, patients with schizophrenia showed enhanced FC between the caudate nucleus and the posterior cingulate cortex, temporal and occipital regions on rsfMRI. It is thus possible that HCs have negative FC between these regions, whereas patients with schizophrenia have non-negative FC. Patients showed trends of local over-connectivity/global underconnectivity in EEG.
Increased FC in the caudate may represent aberrant between-network FC resulting from the disruption of segregation between networks. These findings may reflect aberrant between-network connectivity that results from disruption of segregation between networks.

Free Research Field

ニューロイメージング　機能的MRI　精神生理

Academic Significance and Societal Importance of the Research Achievements

統合失調症の病態にfunctional connectivity (FC)の異常が大きく関わっていることが報告されているが、依然一定の見解は得られていない。最も研究されている脳内ネットワークの一つであるdefault mode network (DMN)に関しても、統合失調症に関する所見は一定ではない。ｆMRI・脳波・拡散MRIの同時測定はそれぞれの手法の持つ利点を最大に生かせる組み合わせである。fMRI・脳波によるfunctionalなモデルに拡散MRIによる解剖学的なモデルを融合することが可能となる。これらの同時測定による統合失調症患者FCの検討は国際的にも例を見ない。