2016 Fiscal Year Final Research Report
The exploration for key imaging molecules relating to brain accumulation of Vitronectin in the mouse model of Tauopathy
| Project/Area Number |
26461760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokushima (2015-2016)
National Institute of Radiological Sciences (2014) |
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Principal Investigator |
MARUYAMA Masahiro 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (80396481)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ビトロネクチン / タウオパチー / 膜侵襲複合体 / 脳萎縮 |
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| Outline of Final Research Achievements |
A final component of complement system, the membrane attack complex（MAC）, affects neuronal dissolution which leads to brain atrophy in the mouse model of tauopathy. MAC acted as a raiding factor by contrast with the vitronectin(Vn) for tau crumbling neuron. The serious atrophy at hippocampus made by such mechanism in the Vn deleted model of tauopathy. It seems that the modulation of Vn-complement system controls the pathology in the tauopathy.
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| Free Research Field |
神経科学
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