Search fo predictive markers of long QT syndrome induced by ADHD therapeutic agents in Children and Adlescents

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461763
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Niigata University
• Principal Investigator: Takuro Sugai 新潟大学, 医歯学総合病院, 講師 (40571914)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 注意欠如・多動性障害（ADHD） / QT延長症候群 / ゲノムワイド関連解析（GWAS） / アトモキセチン / 24時間ホルター心電図

Outline of Final Research Achievements

The sudden cardiac death of children undergoing drug therapy for attention / hyperactivity disorder attracts attention and the influence of drug induced long QT syndrome is assumed as a cause. The QT prolonging action by the drug has large differences among individuals and it is not possible to predict the onset of QT prolongation before drug administration. On the other hand, it is suggested that drug-induced long QT syndrome has an increased risk of onset in individuals with genetic polymorphisms related to QT prolongation, and several single nucleotide polymorphisms (SNPs) are proposed as candidates by genome-wide association study (GWAS) in recent years.
In this study, we investigate the effects of ADHD therapeutic drugs and QT prolonging gene polymorphisms on QT interval using a 24 - hour Holter electrocardiogram and establish an assessment method for cardiovascular event risk in children taking ADHD therapeutic drugs.

Free Research Field

児童思春期精神医学