Investigation into the influences of gene x environment interaction on the emergence of ASD-like behavioral tendecy during early development

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461769
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nagasaki University
• Principal Investigator: DOI Hirokazu 長崎大学, 医歯薬学総合研究科(医学系), 講師 (40437827)
• Co-Investigator(Renkei-kenkyūsha): SHINOHARA Kazuyuki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (30226154)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ASD / 縦断追跡 / 環境 / 遺伝子 / ダイオキシン

Outline of Final Research Achievements

The present study primarily aimed to investigate the influences of gene x environment interaction on the emergence of ASD-like behavioral tendency during early infancy. To achieve this goal, we carried out longitudinal investigation on large cohort of mother-infant pairs, and collected umbilical cord blood samples and the evaluations of ASD-related behavioral tendencies using gaze tracking and questionnaires. Another aim of the present study was to establish an easily-measurable marker of atypical neural function in developmental disorders. The systematic review of fNIRS (functional near-infrared spectroscopy) studies revealed right-lateralization in atypical neural function in children with ADHD, but no consistent pattern was observed in people with ASD.

Free Research Field

認知神経科学