Antioxidant system and medical treatnment in social impairment of autism spectrum disprders

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461777
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyoto University (2016-2017); Dokkyo Medical University (2015); Ashiya University (2014)
• Principal Investigator: Yui Kunio 京都大学, 医学研究科, 客員研究員 (90101352)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 自閉症スペクトラム障害 / 社会性障害 / 酸化ストレス / 抗酸化能 / TAC / HEL / 8-OHdG / superoxide disnutase

Outline of Final Research Achievements

Oxidant/antioxidant imbalance may contribute to the pathophysiology of autism spectrum disorder (ASD). The ASD group exhibited significantly lower urinary TAOC levels and significantly elevated urinary HEL levels than the control group. Urinary 8-OHdG levels and plasma SOD levels were not significantly different between the groups. Standardized regression coefficients revealed that TAOC levels had a larger effect size than HEL levels in urine. This study firstly reveals that an imbalance between urinary HEL and TAOC levels in favor of urinary TAOC levels may contribute to impaired social responsiveness in individuals with ASD.

Free Research Field

神経科学