PD-ECDF-targeted tumor imaging: Development of production system for I-123 labeled compound

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461782
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Nishijima Ken-ichi 北海道大学, 大学病院, 薬剤師 (60364254)
• Co-Investigator(Renkei-kenkyūsha): KUGE YUJI 北海道大学, アイソトープ総合センター, 教授 (70321958) ; ZHAO SONGJI 福島県立医科大学, 福島国際医療科学センター, 教授 (80374239)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 放射性薬剤 / 癌 / チミジンホスホリラーゼ

Outline of Final Research Achievements

The angiogenic factor PD-ECGF/ Thymidine phosphorylase (TP) is expressed at a high level in various solid tumors as compared with the normal tissue. In this study, we aimed to construct an automated manufacturing system for I-123 labeled IIMU that we have developed imaging targeting for PD-ECGF. During this research period, the solution composition of radioactive iodine as a raw material was changed. Therefore, we had to optimize the synthetic condition of I-123 labeled IIMU again. The results of study, it was possible to give I-123 labeled IIMU with the same radiochemical yield as conventional methods. The results of this research gave important knowledge for the automated manufacturing system of the I-123 labeled IIMU.

Free Research Field

医歯薬学