Quantification of breast cancer microenvironment by three dimensional integration of micro bubble contrast ultrasound and MRI image

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461783
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: Takasawa Chiaki 東北大学, 医学系研究科, 非常勤講師 (60623189)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 乳癌 / 血管密度 / 造影超音波 / 定量解析

Outline of Final Research Achievements

The quantitative method of contrast ultrasound is currently equipped with time intensity curve analysis in clinical models. Peak intensity and area under the curve are calculated as parameters, and it is reported that these correlate with MVD. As a new method, we focus on a certain pixel, measure how the color of pixel changes in the time axis direction, divide one with a large degree of change and one with a small change by threshold．We developed a method to detect things as detected pixels of the contrast agent. Finally, an area ratio (enhancement area ratio) of the region where the contrast medium is detected is calculated with respect to the region of interest. In this study, we clarified that the enhancement area ratio correlates with the pathological MVD of invasive cancer.

Free Research Field

画像診断学