Development of the novel imaging probe which used EPR effect

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461784
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: Funaki Yoshihito 東北大学, サイクロトロン・ラジオアイソトープセンター, 講師 (50261491)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ヨウ素124 / イメージングプローブ / 腫瘍

Outline of Final Research Achievements

In labeled synthesis with I-124, un-reacting I-124 was recovered and reuse of I-124 was investigated. It may be considered that I-124 was reused by anion-exchange column. I-124 labeled SIB (succinimidyl iodine benzoate) was synthesized using IODOGEN method. I-124 labeled SIB was obtained by about 50 % of yield. However, I-124 labeled lactosome which is used for an animal experiment was not synthesized.

Free Research Field

核薬学