2016 Fiscal Year Final Research Report
Development of highly-sensitive apoptosis imaging agent based on new drug design
Project/Area Number |
26461785
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
|
Research Institution | Gunma University |
Principal Investigator |
Hanaoka Hirofumi 群馬大学, 大学院医学系研究科, 特任准教授 (50361390)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 放射性医薬品 / アポトーシス |
Outline of Final Research Achievements |
The aim of this study was to develop highly-sensitive apoptosis imaging agent for early prediction of anti-cancer therapy. One of the early biochemical changes of apoptotic cells is exposure of phosphatidylserine (PS) on the external surface of the plasma membrane. The LIKKPF, with high affinity for PS, was selected as a mother compound, then D-amino acid peptide fpkkil-NH2 was designed and prepared considering stability. The fpkkil-NH2 maintained affinity to PS and was stable in vivo. Thus, radiolabeled fpkkil-NH2 derivatives will be useful as apoptosis imaging agents.
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Free Research Field |
放射性医薬品学
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