Development of F-18 radiopharmaceutical for PET imaging of infections

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: Martinez Miguel 福井大学, 高エネルギー医学研究センター, 特命助教 (00631491)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: PET / Infection / Inflammation / Glucosamine / Bacterial imaging agent

Outline of Final Research Achievements

We had reported the radiosynthesis of 2-deoxy-2-[18F]fluoroacetamido-D-glucopyranose, which was able to distinguish infection from inflammation in animal models. Furthermore, we developed new precursors with the same efficiency of [18F]fluoride incorporation under similar radiosynthesis conditions and also developed a high-performance liquid chromatography (HPLC) method for quality control of final [18F]FAG. Final specific activity using tosylate precursor was higher than using bromo precursor. Nevertheless, final specific activity and radiosynthesis yield were lower than previous radiosynthesis procedure therefore not suitable for clinical trials. Finally, the synthesis a new UDP-N-acetylglucosamine precursor was designed and is currently ongoing.

Free Research Field

Nuclear medicine