2016 Fiscal Year Final Research Report
Development of evaluation method for myocardial tissue characterization in patients with ischemic heart disease by using MOLLI MR images on 3T MR scanner.
| Project/Area Number |
26461787
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YOSHITAKA Goto 三重大学, 医学部附属病院, 医員
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | T1マッピング / MOLLI MRI / 細胞外液分画 / 心筋梗塞 / 心筋性状 |
|---|
| Outline of Final Research Achievements |
Rapid innovations in cardiovascular magnetic resonance now permit the routine acquisition of quantitative measures of myocardial T1 which is key tissue characteristics.
We studied its usefulness mainly in patients with ischemic heart disease. As a result, it was shown that in patients with acute myocardial infarction, the extracellular volume fraction and native myocardial T1 are significantly elevated even in non-infarcted myocardium, which is caused by a strong ischemic event following to infarction. In addition, it was shown that the extracellular volume fraction and native myocardial T1 correlate well with the histological fibrosis index. Furthermore, in comparison with late gadolinium enhancement MRI, which is considered to be a gold standard for the non-invasive assessment of myocardial infarction, the non-contrast myocardial T1 could detect myocardial infarction with high accuracy.
|
| Free Research Field |
循環器画像診断
|
