2016 Fiscal Year Final Research Report
MR Hemodynamic Evaluations of Hepatic Vasculatures
| Project/Area Number |
26461791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MURASE KENYA 大阪大学, 医学研究科医用物理工学, 教授 (50157773)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 肝 / 血管内皮機能 / せん断応力 |
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| Outline of Final Research Achievements |
We evaluated newly-developed 4D PC-MRA and MR fluid dynamics (MRFD) for liver vessel and disease assessments. 10 volunteers & 52 patients were enrolled. Vessel visualization were satisfactory and improved after EOB. Hemodynamic assessment could be done in all vessels except for PHAs with diameters of <4mm. Significant differences were only found in all shear stresses in vessel type comparisons. Blood flow and velocity were significantly highest in aorta and lowest in PHA. WSS and SWSSG were significantly highest in CA and lowest in RHV. OSI was significantly highest in aorta and lowest in lt. PV. GON was significantly highest in aorta and lowest in SMV. Significant positive correlation to CP score was found in flow, velocity, WSS, SWSSG of PHA, WSS of SPA, and flow of left PV, and negative one in GON of RHV. Bile duct disorder increased hepatic arterial flow. MRFD can characterize hepatic vessels and WSSs provide additional information in liver disease assessments.
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| Free Research Field |
放射線医学
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