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2016 Fiscal Year Final Research Report

Evaluation of a proper cutoff value on quantitative dual-energy perfusion CT for the assessment of acute pulmonary thromboembolism

Research Project

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Project/Area Number 26461794
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionYamaguchi University

Principal Investigator

KUNIHIRO Yoshie  山口大学, 医学部, 特別医学研究員 (30448310)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsdual-energy CT
Outline of Final Research Achievements

Dual-energy perfusion computed tomography (DEpCT) images were three-dimensionally reconstructed at the following attenuation ranges: 1-2 HU (V2) to 1-10 HU (V10), and 1-120 HU (V120). The ratios of low perfusion areas associated with each threshold range per V120 were also calculated, and the relative ratios were expressed as %V2 to %V10. These values were compared with factors indicating the severity of acute pulmonary thromboembolism (PTE), including the pulmonary arterial pressure, heart rate, CT angiographic obstruction index (CTOI), and right/left ventricular diameter ratio (RV/LV).
The area under the curve (AUC) of %V2 was highest (0.783) among these values based on the presence of intrapulmonary clots. The %V2 showed moderate correlations with CTOI (r=0.36, p=0.005) and RV/LV (r=0.36, p=0.004) in the patients with acute PTE. %V2 exhibit the best correlation with factors suggesting the severity of acute PTE.

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Published: 2018-03-22  

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