2016 Fiscal Year Final Research Report
Development of glutamate imaging agents for Epileptic severity decision
| Project/Area Number |
26461811
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagoya University (2015-2016)
秋田県立脳血管研究センター(研究部門) (2014) |
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Principal Investigator |
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| Research Collaborator |
TATENO MASARU 兵庫県立大学, 生命理学研究科, 教授
KANG JIYOUNG 兵庫県立大学, 生命理学研究科, 特任助教
SATO KAORU 国立医薬品食品衛生研究所, 薬理部, 室長
OHWADA TOMOHIKO 東京大学, 薬学系研究科, 教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | PET / てんかん / グルタミン酸 / 放射性医薬品 / フッ素化 |
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| Outline of Final Research Achievements |
In this study, we examined the imaging agent of tamoxifen derivatives by PET nuclides. The tamoxifen binds to glutamate transporters, but that an effect of inhibiting the glutamate uptake has been reported, on the one hand bind to the estrogen receptor, necessary derivatization are known to have a steroid action .
We synthesized various tamoxifen derivatives without steroid action by reductive coupling reaction between benzophenone derivative and symmetric ketone and examined labeling by [11C] and [18F].
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| Free Research Field |
放射性医薬品化学
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