Development of novel [18F]Fluoroacetate analog for PET Imaging of Ischemic Brain Injury

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461816
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Research Institute, Shiga Medical Center
• Principal Investigator: KAGAWA SHINYA 滋賀県立成人病センター(研究所), 画像研究部門, 主任研究員 (10393191)
• Co-Investigator(Renkei-kenkyūsha): MIZUMA Hiroshi 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員 (00382200)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Benzyl [18F]FACE / フルオロ酢酸 / 脳虚血 / 虚血性脳血管障害 / PET / [18F]FACE

Outline of Final Research Achievements

We reported the relationship between [18F]Fluoroacetate ([18F]FACE) uptake and the number of glial cells in rat ischemia/reperfusion injury and patients with atherosclerotic ICA or MCA disease. Further investigation of brain ischemia using [18F]FACE and the related PET tracers is needed. Therefore, we developed a radiosynthesis of Benzyl [18F]Fluoroacetate (Benzyl [18F]FACE), displayed much higher brain perfusion and retention than [18F]FACE for the purpose of early detection of the ischemic brain injury by PET.

Free Research Field

核医学