Non Gaussian diffusion images for Alzheimer's disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461834
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya University (2015-2016); Nara Medical University (2014)
• Principal Investigator: Toshiaki Taoka 名古屋大学, 医学部附属病院, 病院准教授 (30305734)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アルツハイマー病 / 拡散MRI

Outline of Final Research Achievements

We analyzed cases of Alzheimer’s disease cases using Non-Gaussian diffusion images. The cases were also clinically evaluated including MMSE score and divided into Alzheimer’s disease group, mild cognitive impairment group and subjective cognitive impairment group. By using 3T MR imager, we acquired Non-Gaussian diffusion images and generated diffusion kurtosis images (DKI). DKI showed the decreased diffusion kurtosis in the uncinated fascicles in correlation with severity of the Alzheimer’s disease. That may indicate abnormality in the microstructure of the white matter in the uncinated fascicles which is a part of limbic system.

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