Molecular imaging of gastrointestinal cancer with PET proliferation tracer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461854
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kagawa University
• Principal Investigator: Ono Yuko 香川大学, 医学部附属病院, 講師 (10604952)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 核酸誘導体 / PET / 分子イメージング / 消化器癌 / C-11 4DST

Outline of Final Research Achievements

4DST has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. The purpose of this study was to investigate the feasibility of 4DST PET/CT for the detection of gastrointestinal cancer, in comparison with FDG PET/CT, and determined the degree of correlation between two radiotracers and proliferative activity as indicated by the Ki-67 index. Gastrointestinal cancer were detected by both 4DST and FDG PET/CT studies. A significant correlation was observed between 4DST SUV and FDG SUV. A significant correlation was observed between 4DST SUV and Ki-67 index and for FDG SUV. These preliminary results indicate that 4DST PET/CT seems to be useful in detecting gastrointestinal cancer and in the noninvasive assessment of proliferation, as similar as FDG PET/CT.

Free Research Field

PET分子イメージング