Development of fully automatic quantification methods in nuclear medicine examinations for Parkinson's disease and Parkinson-plus syndromes diagnosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461860
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: Ito Shigeki 熊本大学, 大学院生命科学研究部(保), 教授 (80402395)
• Research Collaborator: OFUJI Asato ; YAMASHITA Kosuke ; OKUMIYA Shintaro ; KAMIYA Yoshito ; TOMIMATSU Taeko ; NAGAOKA Rieko ; KANENAWA Tkayuki ; OTA Satoru ; TANAKA Yudai
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 定量 / 全自動 / パーキンソン病 / 線条体 / 画像解析

Outline of Final Research Achievements

New fully automatic quantification methods using Iodine-123 metaiodobenzylguanidine (123I-MIBG) and Iodine-123 Iofulpane (123I-Ioflupane) have been developed by image analysis according to the pharmacokinetics of 123I-MIBG and 123I-Ioflupane, respectively. The diagnostic accuracy of the new fully automatic methods were superior to the current routine methods. Additionally, the new fully automatic methods improved the repeatability and reproducibility. These methods could be applied as useful and stable methods in routine clinical studies.

Free Research Field

核医学