2016 Fiscal Year Final Research Report
Aqcuisition of radioresistance involving delayed reactive oxygen species
Project/Area Number |
26461863
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
|
Research Institution | Oita University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | gultamate metabolism / oxidative stress / radiosensitivity |
Outline of Final Research Achievements |
We clarified that factors related to the glutamate metabolism pathway lead to radiation sensitivity enhancement among medium components in the cell culture environment. Enhancement of radiosennsitivity by conditioned mediuum from culturing for 4 days could be confirmed in several types of human cancer cell lines, but because it was not seen in normal cells, it is highly likely to be cancer cell specific. As a mechanism, it was confirmed that the reduction of glutathione synthesis by the suppression of the glutamate pathway, and the increase of the oxidative stress accordingly. This result suggests that the glutamate metabolic pathway may be an effective target for cancer killing effects in radiotherapy.
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Free Research Field |
Radiation biology
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