2016 Fiscal Year Final Research Report
Monitoring Mitochondrial Complex-I Activity Using Novel PET Probe 18F-BCPP-EF Allows Early Detection of Radiotherapy Effect in Murine Squamous Cell Carcinoma
| Project/Area Number |
26461871
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Tokai University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | キトコンドリアコンプレックス / MC-I / 放射線治療 / 癌治療効果予測 / ワールブルグ効果 / PET / [18F]FDG / [18F]BCPP-EF |
|---|
| Outline of Final Research Achievements |
Since ionizing radiation is reported to switch aerobic glycolysis to mitochondrial oxidative phosphorylation, radiotherapeutic efficacy was monitored by the activity of mitochondrial complex I (MC-I), using a new PET probe 18F-BCPP-EF, compare with tumor growth suppression in murine squamous cell carcinoma.
In non-irradiated control mice, there was little uptake of 18F-BCPP-EF. In contrast,Tumor uptake of 18F-BCPP-EF increased significantly early (2, 3 or 4 days) after irradiation with effective doses of irradiation, when tumor volume showed no difference irrespective of radiation dose. The results suggest that 18F-BCPP-EF is a promising “positive” MC-I imaging PET probe for early detection of efficacy of tumor radiotherapy.
|
| Free Research Field |
放射線腫瘍生物学、臨床薬理学
|
