2016 Fiscal Year Final Research Report
The effect of HPV status on radiation sensitivity of photon and carbon-ion radiotherapy in head and neck squamous cell carcinoma
| Project/Area Number |
26461878
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | HPV / 頭頸部扁平上皮癌 / p16 |
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| Outline of Final Research Achievements |
HPV related tumors affect the radiation sensitivity in head and neck squamous cell carcinoma. In this study, we performed in vitro experiments and translational research to investigate the different radiation sensitivity between carbon-ion radiotherapy and photon therapy according to HPV status.
At first, we used HPV positive and negative tumors in head and neck squamous cell lines. Clonogenic survival assay was performed to determine radiation sensitivity of carbon-ion radiotherapy and photon therapy. Furthermore, we evaluated HPV status and compared the clinical results in the patients with head and neck squamous cell carcinoma treated with chemoradiotherapy to compare the radiosensitivity.
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| Free Research Field |
放射線腫瘍学
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