Study on image-guided brachytherapy for gynecological tumors

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461879
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: Ohno Tatsuya 群馬大学, 重粒子線医学推進機構, 教授 (10344061)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 放射線治療 / 小線源治療 / 婦人科腫瘍

Outline of Final Research Achievements

We investigate the long-term clinical outcomes of cervical cancer patients treated with in-room computed tomography-based brachytherapy using Japanese standard radiotherapy schedule. The 5-year LC rate according to tumor size were 96%, 91%, and 94% for tumors <4 cm, tumors 4-6 cm, and tumors >6 cm, respectively. The proportions of patients with a high risk clinical target volume (HR-CTV) D90 of >60 Gy (EQD2), D2cc of the rectum of <75 Gy (EQD2), and D2cc of the bladder of <90 Gy (EQD2) were 90%, 99%, and 93%, respectively. There were no significant differences in the HR-CTV D90 among patients with different sized tumors. Then, along with the developing recommendations for contouring HR-CTV for cervical cancer, prospective evaluation in a multicenter setting has been on-going to confirm these findings.

Free Research Field

放射線腫瘍学