Standardization in treatment planning for intensity-modulated radiation therapy for various clinical applications

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461892
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kagawa University
• Principal Investigator: Shibata Toru 香川大学, 医学部附属病院, 教授 (40293857)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 強度変調放射線治療 / 放射線治療計画 / 頭頸部癌 / 標準化

Outline of Final Research Achievements

IMRT is a high-precision technique that can produce optimized dose distributions between the targets and adjacent normal structures. Further developments of standardized technology could play an important role for promoting the application of IMRT for various cancers in Japan. In this research project to help standardization of IMRT treatment planning, we establish a novel 3-arc method for head and neck VMRT to improve planning quality, and a multi-step adaptive scheme for nasopharyngeal VMAT to treatment-induced shrinkage of primary and nodal lesions. We also investigate the impact of pelvic rotational setup error on lymph nodal dose in whole pelvic IMRT using fiducial markers for prostate cancers, to increase the accuracy of dose delivery to lymph node regions. A prospective trial for malignant gliomas using IMRT has been also performed. In this period, we have treated total 181 patients with IMRT, including 78 head-and-neck, 92 prostate, 3 cervical cancers ,and 8 malignant gliomas.

Free Research Field

放射線腫瘍学