The study of stromal cells constituting fibrous stroma for the treatment of liver cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461909
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: IWAISAKO Keiko 京都大学, 医学研究科, 特定講師 (70625300)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 線維化 / 肝癌 / 胆管細胞癌

Outline of Final Research Achievements

In liver cancer, it is thought that various fibrosis presents and supports the progress of cancer. In this study, we aimed to find a new treatment strategy for liver cancer by analyzing cells constituting fibrous cancer stroma. To analysis of clinical samples, we have discriminated "tumor" and "non-tumor" macroscopically and investigated in bulk. However, the microscopically observation revealed that "tumor" tissue markedly increased fibrosis and infiltration of fibroblasts and immune cells. Therefore, using by laser capture microdissection, we isolated cancer stroma and investigated gene expression. It was found that fibrotic genes and marker genes of immune cells were highly expressed in the stroma of cholangiocellular carcinoma. Stroma cells of cholangiocellular carcinoma can be considered as therapeutic targets.

Free Research Field

外科学一般