A study about a novel influence and elucidation of Bevacizumab, molecular targeted drug, on liver regeneration after massive hepatectomy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461913
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: The University of Tokushima (2016); Research Institute, Osaka Medical Center for Maternal and Child Health (2014-2015)
• Principal Investigator: MORI Hiroki 徳島大学, 病院, 助教 (70448330)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 分子標的薬 / Bevacizumab / 大量肝切除 / 肝再生 / 小胞体ストレス応答

Outline of Final Research Achievements

In this study, we investigated the influence on liver function after hepatectomy after Bev administration and the involvement of endoplasmic reticulum stress response during postoperative ischemia-reperfusion injury using 90% hepatectomy model. In the Bev administration group, reduction of liver injury, increase of liver regeneration rate, down-regulation of inflammatory cytokine mRNA expression was observed on the first day after hepatectomy, and furthermore, up-regulation of endoplasmic reticulum stress response-related mRNA expression was confirmed before hepatectomy. Our results suggested that endoplasmic reticulum stress response was involved as a mechanism of positive hepatocyte protection effect by Bevacizumab administration and Bevacizumab improved hepatic dysfunction after hepatectomy via endoplasmic reticulum stress response.

Free Research Field

医歯薬学