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2016 Fiscal Year Final Research Report

A study for improvement of pancreatic islet transplantation outcome by using rare sugar D-allose.

Research Project

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Project/Area Number 26461914
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKagawa University

Principal Investigator

Suzuki Yasuyuki  香川大学, 医学部, 教授 (40304092)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords希少糖 / 膵島移植
Outline of Final Research Achievements

Islet transplantation is a curative treatment option for Type-1 diabetes. The outcome would improve with amelioration of isolated islet function. From the previous experiments, addition of rare sugar D-allose to islet culture medium improved insulin secretion ability and the diabetes cure rate after transplantation. It has been suggested that an antioxidative effect of D-allose may be a mechanism for improving islet function. In addition, in the present experiment, pancreatic islets were transplanted into diabetic model mice, and D-allose was injected to the recipient mice immediately, 24 and 48 hours after transplantation. As a result, the diabetes cure rate was significantly increased compared with the control. We are now investigating the mechanism of this ameliorating effect of D-allose immunohistochemically.

Free Research Field

膵島移植

URL: 

Published: 2018-03-22  

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