2017 Fiscal Year Final Research Report
Telomere length in the liver tissue of bilary atresia
| Project/Area Number |
26461924
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | テロメア / 胆道閉鎖症 / 肝細胞 / 組織Q-FISH法 / 肝予備能 |
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| Outline of Final Research Achievements |
Although biliary atresia (BA) patients can get a long-term survival by Kasai portoenterostomy, some BA patients progress to native liver failure in adulthood. The result of liver transplantation in adult BA patients is poorer than that of in pediatric BA patients. In addition, most adult BA patients cannot have liver transplantation by absence of living donor and impossibility of deceased donor registration. In this study, we evaluated a telomere length of hepatocyte of school-age BA patients because existing hepatocellular reserve biomarkers cannot predict the future native liver failure. These patients with normal results of existing hepatocellular reserve biomarkers showed a shortening of telomere length of hepatocyte. Therefore, we could judge a relative indication of liver transplantation. Telomere length analysis using quantitative fluorescence in situ hybridization could be an objective indicator of hepatocellular reserve capacity in BA patients.
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| Free Research Field |
肝移植
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