MDSC-induced suppression of xenogeneic rejection in combination with gene-modification in porcine endotherial cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461944
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Osaka University
• Principal Investigator: Maeda Akira 大阪大学, 医学系研究科, 招へい研究員 (00319708)
• Co-Investigator(Renkei-kenkyūsha): MIYAGAWA Shuji 大阪大学, 医学系研究科, 准教授 (90273648)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: MDSC / 異種移植 / 拒絶反応 / トレランス

Outline of Final Research Achievements

It has been reported that myeloid-derived suppressor cells (MDSC) are associated with long-term survival and tolerance in transplantation. We demonstrated that monocytic MDSCs are successfully induced from peripheral blood monocytes with our established method and these MDSCs significantly suppressed the xenogeneic rejection by NK cells, cytotoxic T cells and macrophages(Xenotransplantation 2014:21:46-56,Transpl Immunol 2015:33:140-5).
Moreover, we examined the suppression of xenogeneic rejection in gene-modified porcine endothelial cells. Our findings indicate that MDSC has has a potential to induce more powerful tolerance against xenogeneic rejection in combination with generation of gene modified pigs.

Free Research Field

異種移植