Detection for predictive factors of estrogen addition and depletion therapy in endocrine therapy-resistant breast cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461952
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Omoto Yoko 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (80642561)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: エストロゲンレセプター / 乳癌 / 内分泌療法 / ホルモン療法 / ホルモン依存性

Outline of Final Research Achievements

The purpose of this study is to detect predictive factors of endocrine therapy sensitivity of breast cancer. A specimen from estrogen receptor (ER) -positive recurrent breast cancer patient who became aromatase inhibitor (AI) resistant during long-term AI treatment was applied for this study. It was suggested that the non-genomic pathway was involved in the difference in response of AI treatment. Furthermore, we succeeded in pointing out that early ER genetic change is involved in a change in susceptibility to hormonal therapy and we also demonstrated that the blood sample is also possible to use for monitoring of this early gene mutation. Our finding has a possibility to provide a great benefit to breast cancer patients to predict endocrine therapy responsiveness.

Free Research Field

エストロゲンレセプターの分子生物学的機能解析