2016 Fiscal Year Final Research Report
Exploratory study to determine predictive factors of effectiveness of paclitaxel and to establish new therapy for histone modification in anaplastic thyroid cancer.
| Project/Area Number |
26461954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 甲状腺未分化癌 / ヒストン修飾 / EZH2 / 効果予測因子 |
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| Outline of Final Research Achievements |
The purpose of this study is to establish predictive factors of effectiveness of paclitaxel in thyroid cancer and to establish prognostic and therapeutic targets in the epigenetic field. Unfortunately, we could not find predictive factors for paclitaxel in anaplastic thyroid cancer, but the histone modifying enzyme EZH2 overexpression may be associated with the malignancy of thyroid cancer and the expression of Ki67. It turned out that EZH2 is an independent prognostic factor as well as distant metastasis in poorly differentiated thyroid cancer. Currently, we are aiming to establish a new therapy targeting EZH2.
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| Free Research Field |
乳腺内分泌外科学
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