2016 Fiscal Year Final Research Report
Action mechanisms responsible for the development of resistance to endocrine therapy in breast cancer and overcoming the resistance: focusing on a role of breast cancer stem cells
| Project/Area Number |
26461964
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Kawasaki Medical School |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 乳癌 / 癌幹細胞 / エストロゲン / ヘッジホッグシグナル / 内分泌療法抵抗性 / GANT61 / 抗エストロゲン薬 / 細胞増殖抑制 |
|---|
| Outline of Final Research Achievements |
Most breast cancers are estrogen-dependent and sensitive to endocrine therapy. However, resistance to endocrine therapy occurs and makes endocrine therapy ineffective. We focused on a role of breast cancer stem cells in the development of the resistance. Regulatory mechanisms of estrogen on breast cancer stem cells were investigated in vitro. We found that estrogen regulates breast cancer stem cells through estrogen receptor and hedgehog signaling pathway.
|
| Free Research Field |
乳腺外科
|
