2016 Fiscal Year Final Research Report
Elucidation of essential molecular mechanism by which cancer stroma cause the development of peritoneal carcinomatosis into scirrhous gastric cancer.
| Project/Area Number |
26461972
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kanazawa Medical University (2015-2016)
Kanazawa University (2014) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 胃癌 / スキルス胃癌 / 癌性腹膜炎 / 癌間質線維芽細胞 / HGF/MET axis |
|---|
| Outline of Final Research Achievements |
Cancer associated fibroblasts (CAFs) play a crucial role for tumor progression in a variety of malignancy. Activated CAFs frequently express α-smooth muscle actin(SMA) and are classified as myofibroblasts. However, the role and significance of CAFs in gastric cancer progression is still unknown. We investigated the biology of CAFs in human gastric cancers, in particular scirrhous gastric cancer characterized by intense stromal fibroblasts.
We demonstrated that the CAFs in primary site of scirrhous gastric cancer are composed of HGF-producing and both SMA- and fibroblast activation protein (FAP)- expressing activated fibroblasts. Thus, targeting marked HGF production in SMA+ and FAP+ CAFs of scirrhous gastric cancer may result in a clinically effective reduction of tumor progression and dissemination.
|
| Free Research Field |
胃癌 癌性腹膜炎 形成機序解明 新規治療法開発
|
