2016 Fiscal Year Final Research Report
Development of anti-metastasis therapy in the inflammation-related gastric cancer progression
| Project/Area Number |
26461978
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 胃癌 / 慢性炎症 / 微小環境 / 悪性化進展 / p53 |
|---|
| Outline of Final Research Achievements |
Chronic inflammation-related inflammatory microenvironment is a risk factor in gastric cancer development. In this study, we showed the promoting effect of inflammatory microenvironment, such as stromal fibroblast and macrophage, in gastric cancer progression. Moreover, we confirmed that a tumor-specific replication-competent oncolytic adenovirus OBP-702 that induces tumor suppressor p53 gene had a therapeutic potential to induce profound anti-tumor effect against intraperitoneal metastasis of gastric cancer.
|
| Free Research Field |
消化器外科学
|
