2016 Fiscal Year Final Research Report
Analysis of microRNA in esophageal cancer
| Project/Area Number |
26461987
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | microRNA / 食道癌 |
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| Outline of Final Research Achievements |
We reported in our previous paper that miR-23a, miR27b, miR96, miR128b and miR129 are involved in the prognosis of esophageal cancer patients. Especially, miR34b didn't express in the normal tissue, and had high expression in the cancerous tissue.
Because the target genes of miR34b were DLL1 and NOTCH1, and one of a target of miR27b was NOTCH1, we analyzed NOTCH1pathway in esophageal cancer. We recognized that nuclear expression of NOTCH1 was involved in the poor prognosis of esophageal cancer patients. Therefore, NOTCH signal was important in the esophageal cancer.
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| Free Research Field |
医歯薬学
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