2016 Fiscal Year Final Research Report
Establishment of therapeutic models using oncolytic viruses for gastric cancer
| Project/Area Number |
26461992
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 癌治療用ウイルス / ヘルペスウイルス / 胃癌 |
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| Outline of Final Research Achievements |
One of the promising therapeutic strategies for malignancies is an oncolytic virotherapy. We have conducted a study of oncolytic herpes simplex viruses (oHSVs) against gastric cancer. In this project, we examined the antitumor effect of fourth-generation oHSVs, which contains ICP6 gene driven human TERT (telomerase reverse transcriptase) promoter (T-hTERT) and T-SOCS-3 expressing suppressor of cytokine signaling-3. For human gastric cancer cell line, we examined the expression of ribonucleotide reductase (RR) activity and their telomerase activity in gastric cancer cell line, and also evauated the cytotoxicity of T-hTERT and T-SOCS-3. T-hTERT was more effective than T-01 and T-SOCS-3 for all gastric cancer cell lines including MKN1. In addition, we are going to establish the predictive models for therapeutic efficacy using freshly surgical specimens of gastric cancer patients.
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| Free Research Field |
消化器外科学
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