Functional outcomes by reconstruction technique following laparoscopic proximal gastrectomy for gastric cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461997
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokai University
• Principal Investigator: NOMURA Eiji 東海大学, 医学部, 教授 (30288732)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胃癌術後再建法 / Quality of Life / 術後機能評価 / ホルモン分泌動態 / 小腸吸収動態

Outline of Final Research Achievements

Functional outcomes were compared between double tract reconstruction (L-DT, n=15) and jejunal interposition reconstruction (L-JIP, n=15) following laparoscopic proximal gastrectomy (LPG), including laparoscopic total gastrectomy with Roux-en-Y reconstruction (L-TG, n=30) as a control group. Investigations of quality of life (QOL) using a questionnaire and endoscopic examination were performed in each patient, and functional evaluations (kinetics of intestinal absorption and hormonal secretion) were carried out in 10 patients in each group. In comparison to L-TG, L-JIP and L-DT are procedures that maintain nearly preoperative gradual intestinal absorption, and they achieve better postoperative QOL as FPG procedures. Furthermore, the intestinal absorption in the L-DT was not affected by the posture of meal intake, so that L-DT might be superior procedure.

Free Research Field

医歯薬学