2016 Fiscal Year Final Research Report
Biological evaluation and significance of tumor budding using fluorescence immunohistochemistry in pT1b colorectal cancer
| Project/Area Number |
26462007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
NOGAMI Hitoshi 新潟大学, 医歯学総合研究科, 客員研究員 (10547566)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 大腸癌 / 簇出 / 粘膜下層浸潤癌 / リンパ節転移 / 免疫染色 / 内視鏡的粘膜切除術 |
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| Outline of Final Research Achievements |
The purpose of this study was to propose an optimal cut-off value for tumor budding detected by IHC staining for predicting lymph node metastasis in pT1 CRC, and to clarify the clinical significance of tumor budding detected by IHC staining compared to that detected by HE staining.
The optimal cut-off values of tumor budding detected by HE and CAM5.2 staining for predicting lymph node metastasis were 5 and 8, respectively. Based on these cut-off values, tumor budding detected by CAM5.2 staining is inferior to HE staining for predicting lymph node metastasis in pT1 CRC.
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| Free Research Field |
消化器外科学
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