2016 Fiscal Year Final Research Report
Analysis of lipid metabolism as a novel treatment strategy for targeting colon cancer liver metastasis
| Project/Area Number |
26462008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 大腸癌肝転移 / 脂肪酸代謝 |
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| Outline of Final Research Achievements |
In the mouse model of colon cancer liver metastasis, we compared the lipid metabolism profiling between primary tumor and liver metastases by liquid chromatography. However, no significant differences were observed in this experiment. Using the same mouse model, we performed the gene expression analysis by microarray. However, we could not observe any significant differences between primary tumor and liver metastases. Next, we analyzed the protein expression levels that involved in lipid metabolism in surgically resected colon cancer liver metastasis samples by immunohistochemical staining. However, we could not observe any significant differences between primary tumor and liver metastases.
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| Free Research Field |
下部消化管外科
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