2016 Fiscal Year Final Research Report
Development of new therapy targeting MDSC for metastatic advanced colon cancer.
| Project/Area Number |
26462015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 大腸癌 / MDSC / 負の制御 / 原発巣切除 |
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| Outline of Final Research Achievements |
The outcome of patients with malignant tumors is poor if they suffer from lung metastases. Myeloid-derived suppressor cells (MDSCs), a major player for tumor-induced immunosuppression, can be suppressed by certain chemotherapeutic agents, such as low-dose 5- fluorouracil (5-FU) or surgical treatment. Early-phase treatment by low-dose 5-FU chemotherapy and resection of primary tumors improved survival, which was concomitant with a reduction of lung-accumulating MDSCs and lung metastases. Early-phase treatment may provide therapeutic values to prevent MDSC-mediated lung metastasis formation in tumor-bearing hosts.
Secondly, the frequency of MDSCs in the peripheral blood of tumor-bearing mice reflects the status of tumor progression as well as tumor recurrence. Continuous monitoring of MDSCs in the peripheral blood might be a useful indicator of tumor recurrence.
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| Free Research Field |
消化器外科
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