Micro RNAs as promising therapeutic targets for anti-metastatic therapy in colorectal cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462016
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Okayama University
• Principal Investigator: Mori Yoshiko 岡山大学, 医歯薬学総合研究科, 助教 (70708081)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: マイクロＲＮＡ / バイオマーカー / 大腸癌

Outline of Final Research Achievements

The MiRNA array analysis revealed that a set of miRNAs was specifically down-regulated in CRC with BRAF V600E mutation without MSI, considered to be the The MiRNA array analysis revealed that a set of miRNAs was specifically down-regulated in CRC with BRAF V600E mutation without MSI, considered to be the poorer outcome. In vitro, cell lines transfected the set of the miRNAs significantly reduced their malignant potentials. Finally, we analyzed expression level of the set of miRNAs in a cohort of 67 stage IV CRCs. CRCs with the lower expression level of the set of miRNAs showed poor outcome compared with those with the higher expression level. Our data indicate that the miRNAs is promising prognostic biomarkers and therapeutic targets for anti-metastatic therapy in CRC.

Free Research Field

大腸癌