Visceral obesity impacts on adipokine expression and cancer recurrence in patients with colorectal cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462020
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: MIYAMOTO Yuji 熊本大学, 医学部附属病院, 助教 (80551259)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 大腸癌 / 内臓肥満 / アディポカイン / レプチン / 炎症

Outline of Final Research Achievements

We conducted a retrospective study of patients with stage I-III CRC who underwent curative resection to evaluate the correlation between long-term outcome and visceral fat area (VFA) measured by preoperative computed tomography, and to evaluate the impact of the expression of adipokines (leptin, IL-6, VEGF, and TNF-α) in visceral adipose specimens and serum samples on malignant potential.
Patients in the high VFA group had significantly higher recurrence rates than those in the normal VFA group for females (p<0.01) but not for males. Visceral leptin expression had a significant positive correlation with VFA in both genders. Serum levels of leptin and high-sensitivity C-reactive protein were significantly higher in patients with high visceral leptin expression than in those with low visceral leptin expression in females only. Serum leptin expression was independently associated with tumor vascular invasion (p=0.03).

Free Research Field

消化器外科（主に大腸癌）