Isolation and functional analysis of blood circulating tumor cells in colorectal cancer using modified Telomescan system for clinical application

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Juntendo University
• Principal Investigator: Ochiai Takumi 順天堂大学, 医学部, 客員准教授 (10626815)
• Co-Investigator(Kenkyū-buntansha): 小見山 博光 順天堂大学, 医学部, 非常勤講師 (30348982) ; 十合 晋作 順天堂大学, 医学部, 准教授 (80365634)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 大腸癌 / 血中循環癌細胞 / テロメラーゼ / 予後予測因子 / 治療効果判定

Outline of Final Research Achievements

TelomeScan system, developed in Japan,is a method to detect circulating tumor cells (CTC) in peripheral blood by the activity of telomerase which shows high expression in cancer cells. The authors aimed to improve diagnosis of colorectal cancer by CTC detection through application of the TelomeScan system. Density of CTC in blood drawn from each colorectal cancer patients before and after neoadjuvant chemotherapy (NAC). Using this system, more CTCs were detected than with other conventional methods we tested. Density of CTC was seemed to reduced after NACs. It was suggested that CTCs in colorectal cancer should be sensitively detected with the TelomeScan system.

Free Research Field

消化器外科学