2016 Fiscal Year Final Research Report
Interpretation for the mechanism of acquired resistance of EGFR blockade by using cell free DNA
| Project/Area Number |
26462030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 大腸癌 / 抗EGFR抗体 / Liquid biopsy / Circulating DNA / Circulating tumor DNA |
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| Outline of Final Research Achievements |
KRAS mutation is detected in circulating cell-free DNA of 10% of patients with KRAS wild colorectal cancer. EGFR blockade has no cyto-reductive effect in those patients. EGFR blockade has cyto-reductive effect in patients with both KRAS and BRAF wild in primary tumor and circulating cell free DNA. KRAS mutation is detected in circulating cell free DNA of 80% of patients who have got acquired resistance to EGFR blockade. Also, BRAF mutation is detected in circulating cell free DNA of 40% of patients who have got acquired resistance to EGFR blockade.
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| Free Research Field |
消化器外科
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