Inflammation-associated NF-kappaB activation promotes tumor progression in hepato-biliary-pancreatic cancer.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462036
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Chiba University
• Principal Investigator: Kuboki Satoshi 千葉大学, 大学院医学研究院, 助教 (50571410)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Ｐｉｎ１ / ＮＦ－ｋａｐｐａＢ / 肝胆膵領域癌

Outline of Final Research Achievements

Pin1-mediated NF-kappaB activation induced tumor cell proliferation and enhanced EMT, which promoted tumor progression in hepato-biliary-pancreatic cancer. Therefore, increased Pin1 expression in cancer cells was an independent prognostic factor after curative operation. Moreover, Pin1 inhibitors, PiB and Juglone, suppressed tumor cell proliferation in vitro and in animal model. Based on these results, we concluded that Pin1 was a potentially useful therapeutic target in patients with hepato-biliary-pancreatic cancer.

Free Research Field

消化器外科