2016 Fiscal Year Final Research Report
The impact of liver graft preservation using perfluorocarbon in donation after cardiac death liver transplantation.
| Project/Area Number |
26462041
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 心停止肝移植 / Perfluorocarbon |
|---|
| Outline of Final Research Achievements |
The outcome of donation after cardiac death (DCD) liver transplantation is worse compared with that of donation after brain death liver transplantation due to the long hypoxic period of donor warm ischemic time. Perfluorocarbon (PFC) is a compound with high oxygen carrying capacity. We investigated the impact of improved graft oxygenation provided by PFC addition on liver ischemia-reperfusion injury (IRI) and survival after DCD liver transplantation. Biochemical and histopathologic analysis showed that liver graft preservation with PFC attenuated liver IRI. Graft preservation with PFC improved postoperative survival. We are planning further investigations about the impact of PFC on ischemic cholangiopathy.
|
| Free Research Field |
肝移植
|
