2016 Fiscal Year Final Research Report
Relation of P-cadherin and Rho family in intrahepatic cholangiocarcinoma
| Project/Area Number |
26462045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
HORINO Kei 熊本大学, 医学部附属病院, 非常勤診療医師 (60452900)
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| Research Collaborator |
SAKAMOTO Keita 熊本大学, 医学部附属病院, 非常勤診療医師
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | P-cadherin / methylation / unmethylation / promoter / invasion / migration / Rho family |
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| Outline of Final Research Achievements |
P-cadherin overexpression may serve as a useful biomarker of invasive phenotype and poor prognosis. P-cadherin expression was found to be regulated by its promoter methylation. These results suggest that P-cadherin represents a novel therapeutic target for the treatment of intrahepatic cholangiocarcinoma and pancreatic cancer.
However, how P-cadherin affects tumor behavior is still unclear. There is a discrepancy in its role between different cancer types. We should continue a study of mechanism caused by P-cadherin overexpression.
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| Free Research Field |
消化器外科 （肝胆膵外科）
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