2016 Fiscal Year Final Research Report
Development of a novel agent for ultrasound which can show engarftment of transplanted islets and eraly discovery of neuroendocrinal tumor.
| Project/Area Number |
26462053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 膵島移植 / 超音波検査 / 膵内分泌腫瘍 |
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| Outline of Final Research Achievements |
Islet transplantation is a cellular replacement therapy for severe diabetes mellitus. For the success of islet transplantation, it is important to engraft many transplanted islets. However, there are no examinations to evaluate the conditions of transplanted islets directly. Recently, many trials for evaluating the engraftment of islets using imaging examinations have been done. In this study, we tried to evaluate the engraftment and condition of transplanted islets using enhancement ultrasonography, and clarified that echogenicity of the transplanted mouse islets into diabetic mice was increased after injection of contrast agent, and correlation between the echogenicity and metabolic function of the diabetic mice. These findings revealed the possibility of the enhanced ultrasonography for evaluating the engraftment and condition of transplanted islets.
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| Free Research Field |
膵島移植
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